| dc.description.abstract | The prevalence of worm infection in generally is still very high in
Indonesia, between 40-60%. Garlic or Allium sativum is a medical plant widely
used in traditional medicine for the treatment of worm infection. Garlic contains
alisin, active subtance that consists of dialil disulfide, dialil trisulfide, propil alil
disulfide, dialil mono sulfide, alil polisulfide, and squiterpene, garlic is hoped to
have an anthelmintic effect. The aim of this experiment was to know the
anthelmintic effect of the water ekstract of garlic (Allium sativum) againts the dog
hookworm in vitro and learn the value of LC50, LC90, LT50, and LT90 of water
extract of garlic (Allium sativum). This research was an experimental research
with post test only control group design. The samples were 350 the dog
hookworm, which were divided into 7 groups, that is : 6,25%, 12,5%, 25%,
50%,100% concentrations, pirantel pamoat 0,236% as positive control and NaCl
0,9% solutions as negative control. Each group was 5 replicated. Each petri dish
containing 25 ml solutions and 10 worms. The death of worms assessed every
hour until the time limit further research. LC50, LC90 and LT50, LT90 of ekstract
garlic as anthelmintic was calculated using probit analysis methode. Treatment
and control group data were analyzed by the test for differences, using One Way
Annova and continued by Post Hoc Test Bonferroni, with significant level p<0,05.
The rates of kill the the dog hookworm was 18,2 hour’s (18 hour’s 12 minutes).
Water extract of garlic (Allium sativum) has an antihelmintic effect againts the
dog hookworm in vitro with different rates of mortality among the five groups
water extract and control significantly (p<0,05). LC50 values obtained for 33.98%
and 122.26% for LC90. In water extract of garlic 100% concentration has LT50 at
291.87 minutes and 525.86 minutes for LT90. While at concentration of 50%,
25%, 12,5% and 6,25% LT50 and LT90 values greater.
Keywords : Antihelmintic, Garlic (Allium sativum), hookworms. | en_US |
