Preparation And Characterization Of Propranolol Hidrocloride Buccal Mucoadhesive Tablet

Abstract

Propranolol HCl is antihypertensive drug which have low bioavailability (<50%) and short (2-6 hours) elimination half-life. Those problems can be solved by making slow release tablet preparations such us buccal mucoadhesive. Buccal mucoadhesive tablet for the treatment of hypertension propanolol hydrochloride prepared by polymers combination and other excipients. The combination of polymers may affect the delivery of buccal mucoadhesive drugs that can provide controlled release dosage and increase its bioavailability. The purpose of this study to characterize the effect of Carbopol®-HPMC (Hydroxypropyl Methylcellulose) and Carbopol®-CMC Na (Sodium Carboxymethyl Cellulose) as buccal mucoadhesive polymer using direct compression technique. The tablets were evaluated for flow rate and the angle of repose, homogeneity, hardness, friability, uniformity of content, mucoadhesive strength, swelling index, surface pH, propranolol hydrochloride release and dissolution efficiency (DE480). The formula that using the combination of polymer Carbopol® 940P and CMC Na (55:70 mg) was able to provide the best buccal mucoadhesive strength response value. While the formula that using a combination of polymer Carbopol® 940P and HPMC (30:20 mg) has the best DE480 value.