Preparation And Characterization Hollow Microsphere Diclofenac Sodium

Abstract

Diclofenac Sodium was a non-steroidal anti-inflammatory drug that widely used in the treatment of osteoarthritis. However, Diclofenac Sodium has low bioavailability, short half-life and side effects on the gastrointestinal. Thus a controlled release drug was prepared with a multiple unit drug delivery system to increase the effectiveness of the drug and overcome the shortages of the Diclofenac Sodium. The amount of Ethyl Cellulose, HPMC, Ethanol, Polyvinyl Alcohol (PVA), temperature, speed and duration of stirring effect on particle characteristics, drug release rate and entrapment efficiency. This study was aimed to determine the preparation of hollow microspheres Diclofenac Sodium which produces the highest EE value. The best hollow microsphere preparation was found in formula 5 with the highest EE value of 84.568 ± 0.363.