Thrombocyte Counts in Mice After the Administration of Chloroform Fraction of Eleutherine palmifolia L(Merr)

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease that can cause a decrease in the number of thrombocyte cells. Dayak onion bulbs (Eleutherine palmifolia) Is a Kalimantan plant that is thought to increase the number of thrombocyte cells in the blood. This study aims to determine the activity of chloroform fraction of Eleutherine palmifolia on the number of Thrombocyte cells. Experimental research using 25 animals divided into 5 groups, namely chloroform fraction extract dose of 50 mg/ KgBW, dose of 100 mg/ KgBW, dose of 200 mg/ KgBB, saline solution, and Psidii® syrup (positive control). Thrombocyte counts before and at 3 days after dosing revealed significantly higher mean counts after dosing with the as compared to the mean count at hour 0. There was only a non-significant rise of thrombocyte counts in the group having received saline solution in mice. The results showed the administration a dose of 100 mg/ KgBB was able to significantly increase Thrombocyte cells count in mice.