Formulation and evaluation of astaxanthin lotions as natural antioxidants for the skin

Abstract

Antioxidants are compounds used to inhibit free radical activity. Antioxidants derived from natural ingredients are astaxanthin.This study aims to determine the value of IC50 astaxanthin, knowing the effect of adding astaxanthin concentration in antioxidant lotion preparations and determining good lotion formula based on physics, chemical, moisture, stability and antioxidant test results. Antioxidant activity testing was performed using DPPH. The lotion is made by the variation of astaxanthin concentration. Results of antioxidant activity Astaxanthin has a very strong antioxidant activity with IC50 value of 30.45 ppm. The antioxidant activity test of the astaxanthin lotion preparation showed that all formulas had strong antioxidant activity with Formula 1 (1%) 98,961 ppm, Formula 2 (3%) 88,921 ppm and Formula 3 (5%) 87,571 ppm. With the difference in concentration of astaxanthin the higher the concentration the stronger the antioxidant activity. The formula that has the best antioxidant activity is Formula 3 with IC50 87,571 ppm. Physical test results, chemistry, stability test during 28 days storage of astaxanthin lotion preparation showed that the four formulas met the requirements. While the humidity test showed that the preparation of astaxanthin lotion which has the highest percentage of moisture increase is Formula 3.