Physical Stability Test of Ethanol Extract Cream of Kepok Banana Leaves (Musa paradisiaca L.)

Abstract

Kepok banana leaves (Musa paradisiaca L.) contain of active compounds such as tannins, flavonoids and polyphenols has known for wound healing activity in rats. Cream are drug dosage forms which are widely used because comfortable and relatively stable. The aim of this study is to evaluate the physical stability of ethanol extract cream of Musa paradisiaca L. leaves. Cream preparations were made by varying stearic acid concentration, F1 (10%); F2 (15%) and F3 (20%). Physical stability tests carried out on days of 1 and 21 at a low temperature of (4±20C), room temperature (25±20C), and high temperature (40±20C) included organoleptic, spreadability, pH, viscosity, cycling tests, and centrifuges. The research results show that all the formulas showed stable physical characteristics of cream and the best cream preparations is showed on formula F2.