Comparative effectiveness of empiric antibiotics in pediatric community acquired pneumonia patient

Abstract

Community-acquired pneumonia (CAP) is one of the leading caused of death in pediatrics. Immediately after infection diagnosed, the empiric antibiotic should be given. The goal of this research was to compare the effectiveness of empirical antibiotics for hospitalized children with CAP. This research was retrospective observational study by collecting data from patient medical record. Study conducted in one of a government hospital in Central Java, Indonesia in period of January-December 2017. This research involved 77 patient whose met inclusion criteria, divided into an ampicillin-gentamicin group (53) and 3rd generation cephalosporine group (24). There was no significant difference on clinical response in mild and moderate (p=0.485) condition in two group, but significantly different in severe condition (p=0.035). The effectiveness based on length of stay (LOS) in test analysis by Mann-Whitney showed that there was a significant difference in mild (p=0.028) and severe condition (P=0.000), but shown the same effectiveness in moderate condition (p=0.077). The effectiveness based on the rehospitalization showed that there was no significant difference in mild, moderate and severe condition (P = 1,000; p=0.051; p=0.0469). The effectiveness of ampicillin-gentamicin was better than 3rd generation cephalosporine in terms of LOS in children with mild and severe condition.