Disintegrasi dan Disolusi Tablet Furosemida dari Berbagai Produk Generik dan Produk Paten yang Beredar
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The objective ofthis research was to know the in vitro pharmasetical quality of furosemide tablet product that available on the market which has differ on formulation and manufacturing process. Furosemide is a diuretic agent that useful in intensive working and usually used to hypertense and oedema. Disintegration and dissolution test were performed in which samples of the 40 mg strength of fUfUst:mide tablets based on PharmacopeIa1. The dissolution studies suggested that disintegration times ranged from 0 (instanteneous) to 8 minute. The drug dissolution testing was conducted with phosphate buffer at pH 5,8. There appears to be remarkable similarity in overall percentage of drug release from the product. The dissolution rate becoming the rate limiting step of furosemide absorption because furosemide is practice can be dissolved in aqueous medium. The result shows that among to products has Q60 value for each product are A=94,380% , B=91,832% , C=56,381% , D=99,014%, £=97,899%, F=99,872% , G=100,668%, H=79,195% ,1=97,149% and J=76,292%. The conclution is there was a variety in dissolution characteristic profile of the products tested.
- Pharmacy