| dc.description.abstract | Background: Temulawak (Curcuma xanthorrhiza) possesses significant
therapeutic potential but is limited by poor water solubility and instability. Green
synthesis of Gold Nanoparticles (AuNPs) offers a biocompatible solution to
enhance these properties. However, determining the quality profile of these
nanoparticles is essential to ensure their suitability for pharmaceutical use.
Objective: This study aims to evaluate the quality of AuNPs containing Curcuma
xanthorrhiza extract (C-AuNPs) by analyzing their physical and physicochemical
characteristics.
Method: Curcuma xanthorrhiza extract was prepared by maceration using warm
distilled water (40°C) and used for AuNP synthesis with Polyvinyl Alcohol (PVA)
as a stabilizer. The synthesized C-AuNPs were characterized using visual
observation, UV–Vis spectrophotometry, Particle Size Analyzer (PSA), Scanning
Electron Microscopy (SEM)–Energy Dispersive Spectroscopy (EDS), and Fourier
Transform Infrared Spectroscopy (FTIR).
Result: The synthesized C-AuNPs showed a color change from slightly yellowish
to reddish-purple and exhibited Surface Plasmon Resonance (SPR) characteristics
in UV–Vis analysis. Among the tested formulations, F1 showed better stability,
with %T values decreasing from 80.2% at week 0 to 76.1% at week 4, while F2 and
F3 exhibited aggregation during storage. PSA analysis showed particle sizes
ranging from 107.6–132.8 nm with PDI values below 0.7 and zeta potential values
ranging from −14.9 mV to −35.4 mV. SEM analysis revealed predominantly
spherical nanoparticles, while EDS confirmed Au as the dominant element. FTIR
analysis identified several functional groups associated with biomolecules from
Curcuma xanthorrhiza extract.
Conclusion: The synthesized C-AuNPs demonstrated distinct physical and
physicochemical characteristics. Among the tested formulations, F1 exhibited the
most favorable quality profile and stability compared to F2 and F3. | en_US |
