Relationship Between Medication Therapy and Clinical Outcomes of Preeclampsia-Severe Eclampsia: A Study at A.M. Parikesit Tenggarong Hospital, East Kalimantan Province

Abstract

Background: Preeclampsia and severe preeclampsia remain major causes of maternal and neonatal morbidity. Disease severity and therapy play an important role in determining clinical outcomes. Objective: To analyze the association between medication therapy and maternal– neonatal outcomes while considering complications, comorbidities, and prematurity as confounders. Methods: A retrospective cross-sectional study was conducted at A.M. Parikesit Hospital Tenggarong, including 136 patients diagnosed with preeclampsia and

severe preeclampsia from January 2024 to June 2025. Bivariate analysis (Chi- square test) and multivariate logistic regression were performed to identify

associations between medication therapy and maternal–neonatal outcomes. Statistical significance was set at a 5% alpha level. Results: Dignosis was associated with therapy selection, and the analysis revealed differences in anticonvulsant use (OR = 0.034) and combination antihypertensives (OR = 3.22). No association was observed between therapy type and neonatal outcomes. However, maternal complications and prematurity were statistically associated with neonatal outcomes (p < 0.05). Multivariate analysis revealed that absence of comorbidity (OR = 5.36) and oral antihypertensives (OR = 2.51) were associated with maternal stabilization. Conclusion: Maternal outcomes were associated with comorbidity and medication therapy, whereas neonatal outcomes were related to complications and prematurity.