| dc.description.abstract | Background: Propolis, known for its immunomodulatory properties have flavonoids as the main component. However, it was found that flavonoids in propolis have low bioavailability and solubility. One solution to overcome the low solubility and bioavailability of propolis is to produce it in a self-nano- emulsified drug delivery system (SNEDDS) for safe and convenient consumption by the public.
Objective: Obtain an optimal formula that meets the characteristics requirements of the propolis extract SNEDDS preparation.
Methods: The propolis extract is screened for solubility in the oil and surfactant phases. The base is selected then determined the nano-emulsion range with transmittance parameters and presented in the ternary phase diagram. Selected formulations are used to prepare SNEDDS, and each formulation will be characterized based on particle size, transmittance, polydispersity index (PI), and zeta potential. Continued with the thermodynamic stability test for the passed formulation.
Result: The solubility test showed that labrasol (oil phase) and Tween 80 (surfactant) had the highest ability to dissolve the extract. Formula F6 is the selected propolis extract SNEDDS formulation with the composition of 20% labrasol, 60% tween 80, 20% distilled water, and drug loading of 26% propolis extract. The characterization values obtained were particle size 12.620.80 nm, reta potential 33.500.16 mV, polydispersity index 0.36±0.18, and Stransmittance 99.61±0.01%. The preparation was stable during storage. characterized by good results from the thermodynamic stability test, dilution resistance test, and accelerated stability test.
Conclusion: Formula F6 of propolis extract SNEDDS with carrier 20% labrasol, 60% tween 80, and 20% distilled water has fulfilled the characteristics of SNEDDS and is stable during the thermodynamic stability test, dilution resistance test, and accelerated stability test | en_US |
