dc.description.abstract | Based on the decision that issued by BPOM in 2011, topical corticosteroid
(TC) was included in one of the ingredients that has been banned for cosmetics
use because it may cause a variety of dangerous effects. Nevertheless, in Africa,
Asia, and America, TC is misused as a bleaching agent in the form of face cream.
The TC that the most widely abused as a bleaching agent is super potent, potent,
and moderate. This study aims to identify and quantify the TC in the face cream
using thin layer chromatography (TLC)-densitometry. Rf value is the parameter
for the identification, and densitometer is used for the quantification. The
validation resulted that TLC-densitometry method has good validity and it can be
used for identified and quantified the topical corticosteroids in face cream.
Specificity test showed that this method can separated the mixture of
betamethasone valerate and triamcinolone acetonide well, as showed as its
resolution factor was 1,61. R value as the linearity parameter of betamethasone
valerate and triamcinolone acetonide was 0,9995 and 0,9993. The %RSD value of
betamethasone valerate was 1,89% and triamcinolone acetonide was 2,75%.
Accuracy test of betamethasone valerate obtained recovery percentage 97,48%
and triamcinolone acetonide 98,30%. Identification and quantification test
resulted five samples of face cream were not contain betamethasone valerate and
triamcinolone acetonide. | en_US |