Validasi Metode Analisis Bahan Kimia Obat Parasetamol Dan Fenilbutason Dalam Jamu Pegal Linu Dengan Kromatografi Lapis Tipis Densitometri
dc.contributor.advisor | Annisa Fithria | |
dc.contributor.author | Husein, Riana Veda | |
dc.date.accessioned | 2017-11-23T08:09:57Z | |
dc.date.available | 2017-11-23T08:09:57Z | |
dc.date.issued | 2017-04-11 | |
dc.identifier.uri | https://dspace.uii.ac.id/handle/123456789/4424 | |
dc.description.abstract | A traditional Indonesian herbal medicine are much popular with the public because it is believed to nourish the body safely without any side effects. The public confidence to make some herbal manufacturers that utilize the customer's business to improve. One of the efforts is a drug mixing chemicals into the herbal medicine products. Drugs are often mixed them is paracetamol and phenylbutazone into herbal stiff. This study aims to separate paracetamol and phenylbutazone simultaneously in a stiff medicinal product with validated method and added estimation of measurement uncertainty parameter. The method used is the TLC-densitometry. The results obtained for the qualitative test Rf values obtained paracetamol and phenylbutazone respectively 0.55 and 0.38. Quantitative test and validation methods Rf paracetamol and specificity obtained phenylbutazone respectively 0.55 and 0.38, the suitability of the system with the result of 2.615 resolution, linearity with paracetamol linear regression equation y = 30.229x + 273.23 with correlation coefficients (r) 0.9994 and the phenylbutazone linear regression equation y = 10.601x-271.96 with correlation coefficients (r) 0.9995. Limit of Detection (LOD) and Limit of Quantification (LOQ) values respectively paracetamol respectively 4.27 and 12.941 ppm while the LOD and LOQ values are obtained phenylbutazone 19.835 and 60.106 ppm. Precision results obtained from analysis RSD of paracetamol and phenylbutazone are 5.79 and 7.91 %. The accuracy of the results obtained % recovery overall average level of concentration is to paracetamol (89.05 %) and phenylbutazone (95.62 %). The results of samples containing levels of paracetamol along with the estimated uncertainty of measurement ( x ± U) 3.690 ± 0.33965 mg / g. Therefore it can be concluded that this method validation studies meet the parameters set by the United States Pharmacopeia (USP) and Association Of Analytical Chemist (AOAC). | en_US |
dc.publisher | Universitas Islam Indonesia | en_US |
dc.subject | Validation Methods | en_US |
dc.subject | Herbal Medicine | en_US |
dc.subject | Paracetamol | en_US |
dc.subject | Phenylbutazone | en_US |
dc.title | Validasi Metode Analisis Bahan Kimia Obat Parasetamol Dan Fenilbutason Dalam Jamu Pegal Linu Dengan Kromatografi Lapis Tipis Densitometri | en_US |
dc.type | Thesis | en_US |
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Pharmacy [1444]