| dc.description.abstract | Spring-cucumber fruit (Momordica charantia L.) representing one of drug crop
which can be used as well as mucolytic. The aim of this research is to know the
activity of mucolytic of extract of spring-cucumber fruit and detection of chemical
contents.
The research had done with see viscosity change mucus of cow intestine
increased with there are to add solution test. This research use viscometer Ostwald.
Solution test which used is result infundation dry spring-cucumber fruit and extract
ethanol 96% from waste of infundation. Each solution test had invented with the
concentration 0,125%, 0,25%, 0,5%, 1%, 2%, dan 4% b/v, as negative control used
by solution ofmucus 20% and as positive control used by acetylcystein 0,1%.
The mucolytic activity test showed that the water extract and ethanol extract of
spring-cucumber fruit by in vitro method decreased viscosity mucus of cow intestine,
so that drop the viscosity. One way analysis of variance test and the unpared t-test'
indicating result with the difference have ameaning (P <0,05) on the extract ofwater
and no showed with the difference have a meaning on the etanol extract. This matter
indicate that water extract can reduce the viscosity ofmucus or have the character of
mucolytic, whereas ofethanol extract not have the character ofmucolytic.
The result offoam test indicate that the water extract and ethanol 96% extract of
spring-cucumber fruit possibility own the saponin. Pursuant to profile ofTLC use the
stationary phase by silica gel GF254 and mobile phase for the extract of water use by
chloroform-methanol-water (2:1:1) v/v dan for the extract of ethanol used by
chloroform-methanol-air (1:1,5:1,5) v/v, detection for saponin used by Libermann
Burchard reagent, detection for alkaloid used by Dragendorff reagent, indicating that
water extract and etanol extract spring-cucumber fruit may contain the saponin and
alkaloid compound. | en_US |
