| dc.description.abstract | Rheumatoid arthritis is an autoimmune disease which characterized by
inflammation, joint pain, and fatigue. Nephelium lappaceum L. is plant as medicine
herbal. Thereby this research was done to study the effect of ethanol extract of
rambutan's leaf to parameter blood pressure of rheumatoid arthritis case in rat.
Thirthy wistar male rats, 200-250 gram, divided into, 6 (N=5) groupsand they were
given normal food and drink ad libitum. The first group as a normal group. The
second group as a negativegroup induced by Complete Freund's Adjuvant (CFA) 0.1
ml, leaved until 30 days. The third group as a negative control group induced by CFA
0.1 ml. at day 17 until at day 30 after induction they were treated with sodium
diclofenac 0,9mg/200gram Body Weight (g BW) by orally. The fourth, fifth, and
sixth groups induced by CFA 0.1 ml, and then at day 17 they were treated with
extract of rambutan"s leaf until day 30. Extract of rambutan s leave was given orally
with doses at 100 mg extrac/kilogram Body Weight (kg BW), 150mg extract/kg BW,
and 200mg extract/kg BW respectively. Blood pressure parameter was measured at
before induced CFA,at day 17, and day 30 after induction. Blood pressure at day 17
was increased but still in normal range. The data was analyzed statistically with
ANAVA method (p<0,05). The result showed that extract of rambutans leaf and
sodium diclofenac reduced blood pressure significantly in arthritis case rat by CFA
induced, and sodium diclofenac have better reduced percentage than extract of
rambutan's leaf. | en_US |
