EFFECT OF QUERCETIN AND GLIBENCLAMIDE COMBINATION ON CARDIAC MUSCLE NUCLEAR FACTOR KAPPA B (NF-KB) EXPRESSION IN TYPE 2 DIABETIC RATS

Abstract

Type 2 diabetes mellitus is a metabolic disease that often cause cardiomyopathy and heart failure. These complications are caused by free radicals increasing that induced expression of pro inflammatory genes nuclear factor kappa B (NF-KB) and causes cells damage. Quercetin is an antioxidant that can affect the expression of NF-KB and prevent cells damage. The combination of quercetin with oral hypoglycaemic drugs is expected to be a better therapy for type 2 diabetes. The aim of this study is to measure the effects of quercetin and glibenclamide combination on cardiac muscle cells NF-KB expression in type 2 diabetic rats compared with no combination.