ANALYSIS OF THE LEVEL OF PROSTATE SPECIFIC ANTIGEN (PSA) ON MEDICAL CHECK UP (MCU) PARTICIPANTS

Abstract

Background: Prostate Specific Antigen (PSA) is one of the important biomarkers in diagnosis, follow-up, and determining the prognosis of prostate cancer. The use of PSA for initial screening has reduced the incidence of advanced prostate cancer when diagnosed. PSA examination can be used as an effort for men to find out earlier the progress of prostate cancer. This research aims to figure out the distribution of PSA levels on adult male in population of Yogykarta.

Methods: This study uses observational design by taking data from medical record of Medical Check Up (MCU) patient with no complaints. The data of the result of PSA examination is processed in a descriptive way to know the profile of PSA levels on adult male and then it is analyzed to know the relationship toward age.

Results: The research subject is limited to the adult man who undertook medical check up (MCU) in JIH Hospital Yogyakarta, with total of 250 participants fulffiling inclusion and exclusion criteria. Data is taken from 2014-2018. The average level of total serum PSA are 1,42±1,31 ng/ml for the group of below 40 years, 1,05±0,42 ng/ml for the group of 40-49 years old; 2,49±5,02 ng/ml for the group of 50-59 years old; 24,83±122,64 ng/ml for the group of 60-69 years old; 25,54±42,59 ng/ml for the group of 70-79 tahun; and 7,66±6,72 ng/ml for the group of above 80 years old. It shows that level of PSA total serum is getting increase as the age is getting older. This result is in line with previous research in Asian. Statistically, there is a significant correlation between age and PSA levels with r=0,6 and p<0,05.

Conclusion: PSA levels on adult man in Yogyakarta increases along with the increase of age, and those PSA levels is lower than that of other population across the world.