Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease
dc.contributor.author | Wulandari, Nora | |
dc.contributor.author | Fitrianti, Mai | |
dc.contributor.author | Ningsih, Nila Yusmiati | |
dc.date.accessioned | 2018-12-31T08:14:28Z | |
dc.date.available | 2018-12-31T08:14:28Z | |
dc.date.issued | 2018-12-15 | |
dc.identifier.issn | 978-979-98417-5-9 | |
dc.identifier.uri | https://dspace.uii.ac.id/handle/123456789/12321 | |
dc.description.abstract | Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients with various complications that cause polypharmacy which can increase the risk of drug-drug interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse events in geriatric patients with CKD. This was a descriptive study where the samples were collected retrospectively from medical record of the patients admitted in one tertiary care hospital in Jakarta. Potential drug interaction was screened electronically using a drug interaction checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60% with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion, The prevalence of DDIs in geriatric patients with CKD was found high and major level of significance adverse event hyperkalemia was found caused by the DDIs. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Universitas Islam Indonesia, Departement of Pharmacy | en_US |
dc.subject | Drug interaction | en_US |
dc.subject | Geriatric | en_US |
dc.subject | Chronic kidney failure | en_US |
dc.title | Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease | en_US |
dc.type | Article | en_US |