PROCEEDING
http://hdl.handle.net/123456789/12191
2024-03-29T06:30:36ZPreliminari ICPRP 2018
http://hdl.handle.net/123456789/12344
Preliminari ICPRP 2018
Ningrum, Vitarani Dwi Ananda
2018-12-27T00:00:00ZBeeswax increases moisture in lipstick formulation
http://hdl.handle.net/123456789/12343
Beeswax increases moisture in lipstick formulation
Aprillia, Ade Yeni; Inayati H, Hatimah; Yulianti, Rika
Beeswax and Carnauba waxes’ mixture can potentially increase the quality of anthocyanin natural dye lipstick. This study aimed to obtain formulas of different beeswax and carnauba wax mixtures’ contain. Jati leaves was extracted using maseration method. Lipsticks made from Jati leaves extract were added with variations of beeswax and carnauba waxs’ concentration. Each lipstick formula was evaluated for its physical quality, such as homogeneity, melting point, smearing agent, shape, color, and odor stability test, and pH during 4 weeks storage at room temperature, and hedonic and irritation test in rabbit. Jati leaves extract contains anthocyanin proven by qualitative test result using KLT with Rf value 0,1143 and stable at pH 3. Homogenous, orange, and stable lipsticks with melting point at 73-77oC, soft, easy to apply and does not cause irritation against rabbit test animals were obtained. Lipstick’s mixture was increasing along with the increasing of beeswax concentrations.
2018-12-27T00:00:00ZPreparation And Characterization Of Propranolol Hidrocloride Buccal Mucoadhesive Tablet
http://hdl.handle.net/123456789/12342
Preparation And Characterization Of Propranolol Hidrocloride Buccal Mucoadhesive Tablet
Zain, Arini Fitria; Laksono, Bagus Tri; Rahmawati, Putri Aprilina; Munawaroh, Siti; Sari, Lusia Oktora Ruma Kumala; Irawan, Eka Deddy
Propranolol HCl is antihypertensive drug which have low bioavailability (<50%) and short (2-6 hours) elimination half-life. Those problems can be solved by making slow release tablet preparations such us buccal mucoadhesive. Buccal mucoadhesive tablet for the treatment of hypertension propanolol hydrochloride prepared by polymers combination and other excipients. The combination of polymers may affect the delivery of buccal mucoadhesive drugs that can provide controlled release dosage and increase its bioavailability. The purpose of this study to characterize the effect of Carbopol®-HPMC (Hydroxypropyl Methylcellulose) and Carbopol®-CMC Na (Sodium Carboxymethyl Cellulose) as buccal mucoadhesive polymer using direct compression technique. The tablets were evaluated for flow rate and the angle of repose, homogeneity, hardness, friability, uniformity of content, mucoadhesive strength, swelling index, surface pH, propranolol hydrochloride release and dissolution efficiency (DE480). The formula that using the combination of polymer Carbopol® 940P and CMC Na (55:70 mg) was able to provide the best buccal mucoadhesive strength response value. While the formula that using a combination of polymer Carbopol® 940P and HPMC (30:20 mg) has the best DE480 value.
2018-12-27T00:00:00ZAntibiofilm Test of Ethyl Asetate Extract of Jarak Tintir Stem Bark (Jatropha multifida L.) Against Pseudomonas aeruginosa
http://hdl.handle.net/123456789/12341
Antibiofilm Test of Ethyl Asetate Extract of Jarak Tintir Stem Bark (Jatropha multifida L.) Against Pseudomonas aeruginosa
Maghfiratun, Aulia Uffin; Tahmid, Hady Anshory; Fitria, Annisa
Biofilm is defined as colony of microorganism in the extracellular polymeric substance that produced by bacteria. Pseudomonas aeruginosa is a pathogen bacteria that causing acute and chronic infections. Biofilm of Pseudomonas aeruginosa is difficult to be cured because of their resistance against antibiotics. Ethyl acetate extract of Jatropha multifida L. stem bark that contains alkaloids, flavonoids, and phenols are expected as an antibacterial agent. Previous study showed that the ethyl acetate extract of Jatropha multifida L. stem bark has antibiofilm activity against Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) with IC50 values of 300 μg / mL and 760 μg / mL, respectively. The aim of this study was to examine the inhibition and destruction of ethyl acetate extract of Jatropha multifida L. stem bark against biofilm of Pseudomonas aeruginosa. Antibiofilm activity test was performed using crystal violet microtiter plate assay method. The results showed that ethyl acetate extract of Jatropha multifida L. stem bark has biofilm inhibition percentage of 84.90% and biofilm destruction percentage of 75.86% against Pseudomonas aeruginosa at a concentration of 31.25 μg / mL. Ethyl acetate extract of jarak tintir stem bark (Jatropha multifida L.) has antibiofilm activity against Pseudomonas aeruginosa.
2018-12-27T00:00:00Z