This study aims to determine the relationship between self-efficacy and quality of life in patients with cancer. The study included 52 subjects suffering from cancer. The scale used in this study is the World Health Organization Quality of Life (WHOQOL-BREF) by WHO (1996) and general self-efficacy scale created by Barn, Schwarzer and Jerusalem (1995). The hypothesis in this study is the higher Self Efficacy who owned the higher the Quality of Life owned. Scale in this study had a Cronbach alpha value of 0061 to World Health Organization Quality of Life (WHOQOL-BREF) scale and 0.000 of general self-efficacy scale. The results showed a significant relationship between Self Efficacy in Quality of Life with a value of r = 0. 326 and p = 0.005. This study also discusses the implications of weakness about this study.  
Kata kunci: Quality of Lefe, Self effication,patients with cancer