This study aims to analyze the influence of firm size and debt to equity ratio on Corporate Social Responsibility (CSR) and also the influence of corporate social responsibility on company’s profitability. The variable used consists of dependent variable, mediating variable, and independent variable. The dependent variables used is the company's profitability, Return On Asset (ROA), Return on Equity (ROE) and Net Profit Margin (NPM) as a measure of the company’s profitability. Intervening variable used in this research is Corporate Social Responsibility (CSR), while the independent variables are firm size and debt to equity ratio. The sample used in this study were 36 companies that consistently listed on the Indonesia Stock Exchange in the mining sector, in the period of 2012 through 2014. The sample data taken from the financial statements of companies that have been published. The method used in sampling is purposive sampling. The result of this research shows that the Firm Size and Debt To Equity Ratio has significant influence on corporate social responsibility (CSR), and also the corporate social responsibility (CSR) has significant influence on the Return On Asset (ROA), Return on Equity (ROE) and Net Profit Margin (NPM) as a proxy for the profitability ratio. Keywords : firm size, debt to equity ratio, corporate social responsibility (CSR), return on assets (ROA), return on equity (ROE), net profit margin (NPM).