The development of bank industry, particularly Islamic banking or sharia banking, has been growing fast after UU No.7 year 1992 was being amendedto UU No. 10 year 1998.The article states to allow conventional banks to runits activity based on sharia principles accordingtocertain terms set by Bank Indonesia. The more sharia banking developing in Indonesia, the more it needs a certain measurement to increase its banking performances for a healthy andefficient banking based on sharia principles. It cannot be denied that sharia banking is profit oriented as well, therefore its profitability becomes the right measurement to assess sharia banking performances. The higher the profitability of the bank, the better performances of the bank.Return on Asset (ROA) is one of profitability ratios used to measure business effectiveness in making profit by utilizing its total assets. BankIndonesiaas a banking erector and a supervisor, is prioritizing more on the value of profitability which is being measured by its assets that mostly from the public deposits fund. Inthisresearchthewriterused multipleregressionanalysisby observing the period of 1st quarter of 2009 to the 1stquarter of 2015. Meanwhile the variables used for the research areROA, CAR BOPO, NPF, and FDR. The result of the research shows that partially CAR and BOPO does not have effect on the profitability of the bank. Meanwhile NPF has positive effect on FDR and negative effect on ROA. Simultaneously independent variables have effect on its dependent variables. 
Key words: ROA, CAR BOPO, NPF, FDR