DESAIN OPTIMASI DAN EVALUASI FLOATING TABLET RANITIDIN MENGGUNAKAN KOMBINASI POLIMER HPMC DAN CARBOPOL DENGAN METODE SIMPLEX LATTICE DESIGN
Abstract
Ranitidine is a histamine H2 receptor inhibitor in parietal cells that can inhibit
stomach acid production. Ranitidine is commonly used for active duodenal disease,
gastroesophageal reflux and diseases involving high gastric acid secretion. The purpose
of this study is to make ranitidine in the form of floating tablet preparations so as to
increase drug release time and achieve better bioavailability. This study aims to optimize
the design and evaluation of floating tablets with a combination of HPMC and carbopol
using the Simplex Lattice Design method. Systematic work in this study is determining
the ratio of ranitidine floating tablet components; floating tablet preparation formula;
FTIR test; dissolution test; floating lag time test; test duration of buoyancy; size
uniformity test; weight uniformity test; hardness test; friability test; and analysis of result
data. The result of optimal formula ranitidine floating tablet with HPMC and carbopol
components is 130 mg: 32.5 mg. The resulting characterization response got a floating lag
time of 8.21 seconds and dissolution (T50%) 3.29 hours and the duration of buoyance test
results> 7 hours. The formula has a hardness value of 8.21 ± 0.23, fragility of 0.37 ± 0.06,
uniformity of size based on the diameter and thickness of each is 4.48 ± 0.01 and the
results of the uniformity of weights with a value of 4 , 68 which can be stated
uniformly.The result of weight uniformity is stated uniformly. It was concluded that
Simplex Lattice Design can be used to determine the optimal formula ranitidin floating
tablets with characterization results that in criteria.
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